paulthom had an idea of adding help text to a texbox when the programme loads. The help text just explains what to type in the box and needs to disappear once the user types anything or clicks in the box. If you're interested in doing similar, or want to know how to use mouse events, go here:
http://www.daniweb.com/forums/thread128788.html
Aside from being example code that shows you how to implement such a feature, it demonstrates how funny things happen if you don't return focus to the calling widget by typing event.Skip() at the end of the mouse event's handler method.
The wxPython documentation on mouse events is a decent reference: http://www.wxpython.org/docs/api/wx.MouseEvent-class.html