Below is my code

string strpos2 = System.Configuration.ConfigurationManager.AppSettings["arraycolumn"];
        char[] sep2 = { ',' };
        string[] number = strpos2.Split(sep2);

number contain array of string
how can i assign this array of string to int[]

You'll have to convert them:

int[] myInts = new int[number.Length];
for(int i = 0; i < number.Length; i++) {
    if (Int32.TryParse(number[i], out myInts[i]) == false) {
        // conversion failed, it wasn't an integer
    }
}

Thanks Momerath for giving your valuable time
It helped me

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