Can please any one help in understanding the difference between .NET 1.1,2.0,3.0,3.5 and 4.0 ?

The list of differences are huge. In interviews you normally need to short and sweet. So we will list down top 5 differences from each section.

So lets first start with the difference between 1.0 and 2.0.

Support for 64 bit application.
Generics
SQL cache dependency
Master pages
Membership and roles

Now the next difference .NET 2.0 and 3.0
=========================================

WCF
WPF
WWF
WCS ( card space)

3.0 and 3.5
==========================================
LINQ
Ajax inbuilt
ADO Entity framework
ADO data services
Multi targeting

Finally 3.5 and 4.0
===========================================
MEF
Parallel computing
DLR dynamic
Code contract
language runtime
Lazy initialization

great answer

commented: Sock-puppet nonsense. -3
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