pc runs fine for a while, but the longer it runs, the slower it gets before it eventually locks up.

Logfile of Trend Micro HijackThis v2.0.3 (BETA)
Scan saved at 1:39:09 PM, on 2/19/2010
Platform: Windows Vista SP2 (WinNT 6.00.1906)
MSIE: Internet Explorer v8.00 (8.00.6001.18882)
Boot mode: Normal

Running processes:
C:\Windows\system32\taskeng.exe
C:\Windows\system32\Dwm.exe
C:\Windows\Explorer.EXE
c:\PROGRA~1\mcafee.com\agent\mcagent.exe
C:\Program Files\Dell Support Center\bin\sprtcmd.exe
C:\Program Files\Common Files\AOL\1208127756\ee\aolsoftware.exe
C:\Program Files\Google\Google Desktop Search\GoogleDesktop.exe
C:\Windows\System32\igfxpers.exe
C:\Windows\System32\hkcmd.exe
C:\Windows\System32\igfxtray.exe
C:\Windows\system32\igfxsrvc.exe
C:\Windows\RtHDVCpl.exe
C:\Program Files\Dell 968 AIO Printer\dldomon.exe
C:\Program Files\Dell 968 AIO Printer\memcard.exe
C:\Program Files\iTunes\iTunesHelper.exe
C:\Windows\ehome\ehtray.exe
C:\Program Files\Windows Media Player\wmpnscfg.exe
C:\Program Files\Digital Line Detect\DLG.exe
C:\Program Files\McAfee Security Scan\1.0.150\SSScheduler.exe
C:\Windows\ehome\ehmsas.exe
C:\Program Files\Google\Google Desktop Search\GoogleDesktop.exe
C:\Program Files\Common Files\AOL\1208127756\ee\anotify.exe
C:\Program Files\TrendMicro\HiJackThis\HiJackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Window Title = Internet Explorer provided by Dell
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O1 - Hosts: ::1 localhost
O2 - BHO: AcroIEHelperStub - {18DF081C-E8AD-4283-A596-FA578C2EBDC3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelperShim.dll
O2 - BHO: AskBar BHO - {201f27d4-3704-41d6-89c1-aa35e39143ed} - C:\Program Files\AskBarDis\bar\bin\askBar.dll (file missing)
O2 - BHO: Spybot-S&D IE Protection - {53707962-6F74-2D53-2644-206D7942484F} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O2 - BHO: SSVHelper Class - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre1.6.0\bin\ssv.dll
O2 - BHO: AOL Toolbar Loader - {7C554162-8CB7-45A4-B8F4-8EA1C75885F9} - C:\Program Files\AOL Toolbar\aoltb.dll
O2 - BHO: scriptproxy - {7DB2D5A0-7241-4E79-B68D-6309F01C5231} - C:\Program Files\McAfee\VirusScan\scriptsn.dll
O2 - BHO: Google Toolbar Helper - {AA58ED58-01DD-4d91-8333-CF10577473F7} - C:\Program Files\Google\Google Toolbar\GoogleToolbar.dll
O2 - BHO: Google Toolbar Notifier BHO - {AF69DE43-7D58-4638-B6FA-CE66B5AD205D} - C:\Program Files\Google\GoogleToolbarNotifier\5.0.926.3450\swg.dll
O2 - BHO: Google Dictionary Compression sdch - {C84D72FE-E17D-4195-BB24-76C02E2E7C4E} - C:\Program Files\Google\Google Toolbar\Component\fastsearch_219B3E1547538286.dll
O2 - BHO: Browser Address Error Redirector - {CA6319C0-31B7-401E-A518-A07C3DB8F777} - C:\Program Files\Dell\BAE\BAE.dll
O3 - Toolbar: &Google Toolbar - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - C:\Program Files\Google\Google Toolbar\GoogleToolbar.dll
O3 - Toolbar: AOL Toolbar - {DE9C389F-3316-41A7-809B-AA305ED9D922} - C:\Program Files\AOL Toolbar\aoltb.dll
O3 - Toolbar: Ask Toolbar - {3041d03e-fd4b-44e0-b742-2d9b88305f98} - C:\Program Files\AskBarDis\bar\bin\askBar.dll (file missing)
O4 - HKLM\..\Run: [DellSupportCenter] "C:\Program Files\Dell Support Center\bin\sprtcmd.exe" /P DellSupportCenter
O4 - HKLM\..\Run: [HostManager] C:\Program Files\Common Files\AOL\1208127756\ee\AOLSoftware.exe
O4 - HKLM\..\Run: [Google Desktop Search] "C:\Program Files\Google\Google Desktop Search\GoogleDesktop.exe" /startup
O4 - HKLM\..\Run: [Persistence] C:\Windows\system32\igfxpers.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\Windows\system32\hkcmd.exe
O4 - HKLM\..\Run: [IgfxTray] C:\Windows\system32\igfxtray.exe
O4 - HKLM\..\Run: [RtHDVCpl] RtHDVCpl.exe
O4 - HKLM\..\Run: [Windows Defender] %ProgramFiles%\Windows Defender\MSASCui.exe -hide
O4 - HKLM\..\Run: [dldomon.exe] "C:\Program Files\Dell 968 AIO Printer\dldomon.exe"
O4 - HKLM\..\Run: [MemoryCardManager] "C:\Program Files\Dell 968 AIO Printer\memcard.exe"
O4 - HKLM\..\Run: [mcagent_exe] "C:\Program Files\McAfee.com\Agent\mcagent.exe" /runkey
O4 - HKLM\..\Run: [Adobe Reader Speed Launcher] "C:\Program Files\Adobe\Reader 9.0\Reader\Reader_sl.exe"
O4 - HKLM\..\Run: [Adobe ARM] "C:\Program Files\Common Files\Adobe\ARM\1.0\AdobeARM.exe"
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\QTTask.exe" -atboottime
O4 - HKLM\..\Run: [iTunesHelper] "C:\Program Files\iTunes\iTunesHelper.exe"
O4 - HKLM\..\RunOnce: [Uninstall Adobe Download Manager] "C:\Windows\system32\rundll32.exe" "C:\Program Files\NOS\bin\getPlus_Helper.dll",Uninstall /IE2883E8F-472F-4fb0-9522-AC9BF37916A7 /Get1noarp
O4 - HKCU\..\Run: [DellSupportCenter] "C:\Program Files\Dell Support Center\bin\sprtcmd.exe" /P DellSupportCenter
O4 - HKCU\..\Run: [ehTray.exe] C:\Windows\ehome\ehTray.exe
O4 - HKCU\..\Run: [WMPNSCFG] C:\Program Files\Windows Media Player\WMPNSCFG.exe
O4 - HKUS\S-1-5-18\..\Run: [DelayShred] c:\PROGRA~1\mcafee\mshr\ShrCL.EXE /P7 /q C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\5WGCU53E\IFRAME~3.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\G64Y0MA6\RANDOM~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\M5CQCIEN\OPENHA~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\03NTI4ID\LOAD_V~4.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\EHJHCJCY\TPP_1_~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\WWVQBUE2\PASS_1~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\2A8SC240\TCODEB~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\I5QNF5TJ\OPTN_6~2.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\5WGCU53E\SIZE_1~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\2A8SC240\AIMRAD~2.SH! C:\
O4 - HKUS\.DEFAULT\..\Run: [DelayShred] c:\PROGRA~1\mcafee\mshr\ShrCL.EXE /P7 /q C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\5WGCU53E\IFRAME~3.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\G64Y0MA6\RANDOM~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\M5CQCIEN\OPENHA~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\03NTI4ID\LOAD_V~4.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\EHJHCJCY\TPP_1_~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\WWVQBUE2\PASS_1~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\2A8SC240\TCODEB~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\I5QNF5TJ\OPTN_6~2.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\5WGCU53E\SIZE_1~1.SH! C:\Users\DAVE~1.JEN\AppData\Local\MICROS~1\Windows\TEMPOR~1\Content.IE5\2A8SC240\AIMRAD~2.SH! C:\
O4 - Global Startup: Digital Line Detect.lnk = C:\Program Files\Digital Line Detect\DLG.exe
O4 - Global Startup: McAfee Security Scan.lnk = ?
O8 - Extra context menu item: &Search - ?p=ZNfox000
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0\bin\npjpi160.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0\bin\npjpi160.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~3\OFFICE11\REFIEBAR.DLL
O9 - Extra button: (no name) - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra 'Tools' menuitem: Spybot - Search & Destroy Configuration - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O13 - Gopher Prefix:
O20 - AppInit_DLLs: C:\PROGRA~1\Google\GOOGLE~2\GOEC62~1.DLL
O22 - SharedTaskScheduler: Component Categories cache daemon - {8C7461EF-2B13-11d2-BE35-3078302C2030} - C:\Windows\system32\browseui.dll
O23 - Service: Andrea RT Filters Service (AERTFilters) - Andrea Electronics Corporation - C:\Windows\system32\AERTSrv.exe
O23 - Service: AOL Connectivity Service (AOL ACS) - AOL LLC - C:\Program Files\Common Files\AOL\ACS\AOLAcsd.exe
O23 - Service: Apple Mobile Device - Apple Inc. - C:\Program Files\Common Files\Apple\Mobile Device Support\bin\AppleMobileDeviceService.exe
O23 - Service: Bonjour Service - Apple Inc. - C:\Program Files\Bonjour\mDNSResponder.exe
O23 - Service: dldoCATSCustConnectService - Unknown owner - C:\Windows\system32\spool\DRIVERS\W32X86\3\\dldoserv.exe
O23 - Service: dldo_device - - C:\Windows\system32\dldocoms.exe
O23 - Service: iPod Service - Apple Inc. - C:\Program Files\iPod\bin\iPodService.exe
O23 - Service: McAfee Services (mcmscsvc) - McAfee, Inc. - C:\PROGRA~1\McAfee\MSC\mcmscsvc.exe
O23 - Service: McAfee Network Agent (McNASvc) - McAfee, Inc. - c:\PROGRA~1\COMMON~1\mcafee\mna\mcnasvc.exe
O23 - Service: McAfee Scanner (McODS) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcods.exe
O23 - Service: McAfee Proxy Service (McProxy) - McAfee, Inc. - c:\PROGRA~1\COMMON~1\mcafee\mcproxy\mcproxy.exe
O23 - Service: McAfee Real-time Scanner (McShield) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcshield.exe
O23 - Service: McAfee SystemGuards (McSysmon) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcsysmon.exe
O23 - Service: McAfee Personal Firewall Service (MpfService) - McAfee, Inc. - C:\Program Files\McAfee\MPF\MPFSrv.exe
O23 - Service: ProtexisLicensing - Unknown owner - C:\Windows\system32\PSIService.exe
O23 - Service: SBSD Security Center Service (SBSDWSCService) - Safer Networking Ltd. - C:\Program Files\Spybot - Search & Destroy\SDWinSec.exe
O23 - Service: SupportSoft Sprocket Service (dellsupportcenter) (sprtsvc_dellsupportcenter) - SupportSoft, Inc. - C:\Program Files\Dell Support Center\bin\sprtsvc.exe
O23 - Service: stllssvr - MicroVision Development, Inc. - C:\Program Files\Common Files\SureThing Shared\stllssvr.exe
O23 - Service: Viewpoint Manager Service - Viewpoint Corporation - C:\Program Files\Viewpoint\Common\ViewpointService.exe
O23 - Service: XAudioService - Conexant Systems, Inc. - C:\Windows\system32\DRIVERS\xaudio.exe

--
End of file - 10799 bytes

You have entries in your HJT log for autostarting programs which appear to contain Temp files. Have never seen this. It is a program called DelayShred which is apparently McAfee's Shredder for cleaning files after closing a session in Internet Explorer. This doesn't need to run at start up and should be turned off. I am not familar with the program, but I know it doesn't need to run at start up. You can use QuickClean manually via McAfee Security Center and run it from there"
Other than that I see no indication of infection in there, and that isn't infection, just an unneeded auto start.
How much RAM do you have installed?

pc runs fine for a while, but the longer it runs, the slower it gets before it eventually locks up.

You should probably try to rule out over-heating as an issue as well as what Judy suggests....

PP:)

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